Download ebook - Domino and Intramolecular Rearrangement Reactions As Advanced Synthetic Methods in Glycoscience (2016, Hardcover) DJV, TXT, DOC
9781119044208 English 1119044200 Domino and Intramolecular Rearrangement Reactions is the first book to provide a much-needed comprehensive state of the art in domino/cascade reactions and rearrangements in the carbohydrate field. It is worth noting that the methodology, is particularly suited for multi-step and total syntheses and when preserving chirality of molecules is crucial. The editors, Witczak and Bielski, have recognized the strategic importance of applying these tools of modern synthetic methodology to carbohydrate chemistry. A group of outstanding scientists have been assembled to address important aspects of the molecular transformations with a combination of rearrangements and cascade/domino options to cover crucial topics within glycosciences. Carefully selected subjects are presented in a collection of 15 chapters, describing recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. The editors cover the broadest scope of novel methodologies possible, exploring all the synthetic and application aspects of domino/cascade reactions. A second theme covers intramolecular rearrangements, which are almost always fast, stereoselective, and often constitute one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. The book constitutes a valuable source of practical information to all carbohydrate chemists. Book jacket., The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 ? 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.
9781119044208 English 1119044200 Domino and Intramolecular Rearrangement Reactions is the first book to provide a much-needed comprehensive state of the art in domino/cascade reactions and rearrangements in the carbohydrate field. It is worth noting that the methodology, is particularly suited for multi-step and total syntheses and when preserving chirality of molecules is crucial. The editors, Witczak and Bielski, have recognized the strategic importance of applying these tools of modern synthetic methodology to carbohydrate chemistry. A group of outstanding scientists have been assembled to address important aspects of the molecular transformations with a combination of rearrangements and cascade/domino options to cover crucial topics within glycosciences. Carefully selected subjects are presented in a collection of 15 chapters, describing recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. The editors cover the broadest scope of novel methodologies possible, exploring all the synthetic and application aspects of domino/cascade reactions. A second theme covers intramolecular rearrangements, which are almost always fast, stereoselective, and often constitute one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. The book constitutes a valuable source of practical information to all carbohydrate chemists. Book jacket., The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 ? 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.